University of Arkansas, Fayetteville Division of Agriculture
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Abstract

The sustained release properties of regular and waxy rice starches and their derivatives were studied in tablets. The starches were cross-linked to different levels with epichlorohydrin, and the sustained release properties, swelling power, and rheological characteristics of the matrices prepared were determined. Propranolol hydrochloride was used as a model drug. The sustained release properties of waxy rice starch improved with increasing cross-linking levels, whereas cross-linking had little impact on the functionality of regular rice starch matrices. There was an increase in swelling power for both regular and waxy rice starches as cross-linking levels increased. Both starches showed an increase in the storage modulus when cross-linking was increased, with the regular rice starch matrices showing greater differences among samples. Regular rice starch matrices showed an independence of frequency as cross-linking increased, indicating a “true gel” characteristic, whereas waxy rice matrices behaved as a “weak gel.” Both regular and waxy rice starches displayed a decrease in creep and recovery profiles with an increase in cross-linking level. Waxy rice starch showed potential as a sustained release agent in tablets.

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