Date of Graduation
Doctor of Philosophy in Chemistry (PhD)
Chemistry & Biochemistry
Matthias C. McIntosh
Second Committee Member
Third Committee Member
Pure sciences; Antascomicin B.; Asymmetric transfer hydrogenation; Organic; Total synthesis
The following dissertation describes synthetic efforts toward the synthesis of the C21-C34 fragment of antascomicin B. Our initial enzymatic approach is detailed as well as an asymmetric transfer hydrogenation (ATH) strategy that will be used in the eventual total synthesis of the molecule. Several investigations into anomalies observed during (ATH) reactions are also discussed.
Clay, David Ross, "Studies Toward the Total Synthesis of Antascomicin B" (2012). Theses and Dissertations. 550.