Microwave chemistry and a Design of Experiments (DOE) protocol were employed together in order to rapidly and efficiently optimize a modified Perkin reaction. Microwave heating significantly reduced the reaction time, and the DOE provided a statistically significant understanding of underlying process relationships in a minimum number of experimental runs. In all, the reaction time was reduced from1hour to 2 minutes, factors important to yield were identified, an interesting cross-term interaction was discovered, and it was demonstrated that the more economical sodium acetate trihydrate catalyst was a viable alternative to the more costly anhydrous sodium acetate.
Pace, R. David and McWilliams, Laura
"Perkin Reaction: Rapid and Efficient Process Optimization Through a Microwave/Design of Experiments Couple,"
Journal of the Arkansas Academy of Science: Vol. 60
, Article 15.
Available at: http://scholarworks.uark.edu/jaas/vol60/iss1/15