We present the preliminary results of a study of two novel thiosemicarbazones (TSCs) and theirruthenium complexes. The TSCs were prepared by refluxing thiosemicarbazide with 9-anthraldehyde or benzanthrone in ethanol for 3 hours. The metal complex of each ligand (complex I =[(r|6 -C6H6 )Ru(9-ant-TSC )(C1)]C1 and complex II= [(r|6 -C6H6 )Ru(benz-TSC)(Cl)]Cl) was prepared by refluxing the appropriate TSC with [(r|6 -C6H6 )RuCl 2 ] r The compounds were characterized using infrared, ultraviolet-visible, and NMRspectroscopy. Two different methods, the disk diffusion test and luminometry, were used to test the compounds against a variety of different bacterial strains for antibacterial activity. The most optimistic results were obtained for the 9-ant-TSC ligand, especially in relation to activity against Gram (+) bacteria. The metal complexes showed no measurable activity and further biological testing of the metal complexes is currently being conducted.
Beckford, Floyd A. and Holt, Amon T.
"Organometallic Ruthenium Complexes of Novel Thiosemicarbazones,"
Journal of the Arkansas Academy of Science: Vol. 60
, Article 6.
Available at: http://scholarworks.uark.edu/jaas/vol60/iss1/6