Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Chemistry and Biochemistry
National University Corporation Kagawa University (Kagawa, JP) Ochsner Clinic Foundation (New Orleans, LA) The Board of Trustees of the University of Arkansas (Little Rock, AR)
Gensure, Robert C.; Sakon, Joshua; Matsushita, Osamu; and Ponnapakkam, Tulasi, "Fusion Proteins of Collagen-Binding Domain and Parathyroid Hormone" (2015). Patents Granted. 1.