Vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector are provided. Compositions comprising the vaccine vectors and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration are also provided . Methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
US8956618; AU2011207331 (C1); CN102811734 (B); EA023058 (B1)
The Texas A&M University System (College Station, TX); Board of Trustees of the University of Arkansas (Little Rock, AR)
Berghman, Luc; Bottje, Walter G.; Hargis, Billy M.; and Layton, Sherryll, "Vaccine vectors and methods of enhancing immune responses" (2015). Patents Granted. 13.