Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites are also provided.
Animal Science; Food Science; Poultry Science
Board of Trustees of the University of Arkansas (Little Rock, AR); The Texas A&M University System (College Station, TX); The University of Guelph (Guelph, Ontario, CA)
Bottje, Walter G.; Hargis, Billy M.; Berghman, Luc; Kwon, Young M.; Cole, Kimberly; Cox, Mandy; Layton, Sherryll; El-Ashram, Said; Barta, John; and Tellez, Guillermo L., "Compositions and methods of enhancing immune responses to Eimeria" (2015). Patents Granted. 14.