Describes a method of producing active immunity against a viral disease in an animal subject. It comprises of administering a vaccine conjugate consisting essentially of a live virus and a neutralizing factor bound to the live virus to the subject. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus.
Chemistry and Biochemistry
EP0755684 (B1); DE69033728 (T2); DK0755684 (T3); ES2158200 (T3)
(UNIVERSITY OF ARKANSAS)
Whitfill, Craig E.; Fredericksen, Tommy L.; Tyczkowski, Julius K.; Thaxton, James P. Jr.; and Thoma, John A., "Vaccine conjugate" (2001). Patents Granted. 173.