Peptoids capable of inhibiting or reversing amyloid .beta. (A.beta.) fibril or plaque production are described. The peptoids form a helical structure with three monomers per helical turn and have at least two monomers with a side-chain having an arylalkyl group having the same chirality positioned such that the side-chains are on the same side of the peptoid. Methods of using the peptoids to inhibit or reverse aggregation of A.beta of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD are also provided.
Board of Trustees of the University of Arkansas (Little Rock, AR); University of South Carolina (Columbia, SC)
Servoss, Shannon and Moss, Melissa, "Peptoids and methods for treating alzheimer's disease" (2014). Patents Granted. 23.