A method of producing active immunity against infectious bursal disease virus in an avian subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. A preferred route of administration to birds is by in ovo administration.
Chemistry and Biochemistry
EP0495008 (B1); DE69030383 (T2); DK0495008; ES2102368 (T3)
UNIV ARKANSAS [US]
Whitfill, Craig E.; Fredericksen, Tommy L.; Tyczkowski, Julius K.; Thaxton, James P. Jr.; and Thoma, John A., "Vaccine conjugate for treatment of avian diseases" (1997). Patents Granted. 294.