Document Type

Patent

Publication Date

2-28-2017

Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Department

Chemistry and Biochemistry

Patent Number

US9579273

Application Number

US 20140377215 A1

Application Published

12-25-2014

Application Filed

12-14-2012

Assignee

The Kitasato Institute (JP); National University Corporation Kagawa University (JP); Montefiore Medical Center (New York, NY); The Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry

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