Fusion proteins of collagen-binding domain and parathyroid hormone

Inventors

Robert C. Gensure
Joshua Sakon, University of Arkansas, Fayetteville
Osamu Matsushita
Tulasi Ponnapakkam

Document Type

Patent

Publication Date

12-27-2016

Abstract

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Department

Chemistry & Biochemistry

Patent Number

US9528099

Application Number

US 20150284701 A1

Application Published

10-8-2015

Application Filed

6-18-2015

Assignee

Ochsner Clinic Foundation (New Orleans, LA); National University Corporation Kagawa University (Kagawa, JP); Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Citation

Gensure, R. C., Sakon, J., Matsushita, O., & Ponnapakkam, T. (2016). Fusion proteins of collagen-binding domain and parathyroid hormone. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/334