Document Type

Patent

Publication Date

12-27-2016

Abstract

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Department

Chemistry and Biochemistry

Patent Number

US9528099

Application Number

US 20150284701 A1

Application Published

10-8-2015

Application Filed

6-18-2015

Assignee

Ochsner Clinic Foundation (New Orleans, LA); National University Corporation Kagawa University (JP); The Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

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