Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
Chemistry and Biochemistry
US 20150038423 A1
The Kitasato Institute (JP); Montefiore Medical Center (New York, NY); The Board of Trustees of the University of Arkansas (Little Rock, AR)
Ponnapakkam, Tulasi; Philominathan, Sagaya Theresa Leena; Sakon, Joshua; Katikaneni, Ranjitha; Koide, Takaki; Matsushita, Osamu; and Gensure, Robert C., "Delivery of therapeutic agents by a collagen binding protein" (2016). Patents Granted. 335.