Fusion proteins of collagen-binding domain and parathyroid hormone

Inventors

Robert C. Gensure
Joshua Sakon, University of Arkansas, Fayetteville
Osamu Matsushita
Tulasi Ponnapakkam

Document Type

Patent

Publication Date

7-23-2019

Abstract

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Department

Chemistry & Biochemistry

Patent Number

US10358471

Application Number

US 20190135890 A1

Application Published

5-5-2019

Application Filed

1-16-2019

Assignee

Board of Trustees of the University of Arkansas (Fayetteville, AR); Ochsner Clinic Foundation (New Orleans, LA); National University Corporation Kagawa University (Kagawa, JP)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Citation

Gensure, R. C., Sakon, J., Matsushita, O., & Ponnapakkam, T. (2019). Fusion proteins of collagen-binding domain and parathyroid hormone. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/360