Document Type

Patent

Publication Date

5-28-2013

Abstract

Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.

Department

Chemistry and Biochemistry

Patent Number

US8450366

Application Number

US20100331370

Application Published

12-30-2010

Application Filed

6-30-2010

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Matthias C. McIntosh, Department of Chemistry and Biochemistry

Share

COinS