Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone and parathyroid hormone related peptide coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Chemistry and Biochemistry
US8450273; EP2155874 (B1); JP5520811 (B2)
Board of Trustees of the University of Arkansas (Little Rock, AR) Ochsner Clinic Foundation (New Orleans, LA) National University Corporation Kagawa University (Takamatsu-shi, Kagawa, JP)
Sakon, Joshua; Gensure, Robert C.; and Matsushita, Osamu, "Fusion proteins of collagen-binding domain and parathyroid hormone" (2013). Patents Granted. 39.