Fusion proteins of collagen-binding domain and parathyroid hormone

Inventors

Joshua Sakon, University of Arkansas, Fayetteville
Robert C. Gensure
Osamu Matsushita

Document Type

Patent

Publication Date

5-28-2013

Abstract

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone and parathyroid hormone related peptide coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Department

Chemistry & Biochemistry

Patent Number

US8450273; EP2155874 (B1); JP5520811 (B2)

Application Number

US20100129341

Application Published

5-27-2010

Application Filed

4-9-2008

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR); Ochsner Clinic Foundation (New Orleans, LA); National University Corporation Kagawa University (Kagawa, JP)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Citation

Sakon, J., Gensure, R. C., & Matsushita, O. (2013). Fusion proteins of collagen-binding domain and parathyroid hormone. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/39