Methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected are described. In addition to methods of treating a subject infected with a pathogenic bacterium using bacteriophage, of decontaminating objects using bacteriophage, of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are also disclosed.
The United States of America, as Represented by the Secretary of Agriculture (Washington, DC), Board of Trustees of the University of Arkansas (Little Rock, AR)
Hargis, Billy M.; Higgins, Stacy E.; Bielke, Lisa R.; Tellez, Guillermo L.; Newberry, Lisa A.; Nava, Gerardo; Donoghue, Ann M.; and Donoghue, Daniel J., "Method for Bacteriophage Delivery and Amplification" (2013). Patents Granted. 44.