Date of Graduation
Bachelor of Science
Committee Member/Second Reader
Committee Member/Third Reader
My research efforts were directed toward the structure and functionality of a protein, designated SpoIIE , which previously has been shown to regulate C. difficile peptide utilization in addition to sporulation and toxin release. The SpoIIE protein is found in all spore-forming gram-positive bacteria and is a crucial component in activation of transcription factors and septum formation thus affecting the regulation and timing of spore development [11,12]. A truncated form of the SpoIIE protein named SpoIIE∆TM was used in an effort to determine the structure of an important but uncharacterized linker domain of the protein. If the structure and specific function of this region were to be discovered, it would provide valuable information regarding the complex reaction cycle of SpoIIE and its relevant virulence factors.
SpIIE, C. difficile peptide, bacteria, spore, virulence, sequencing factors
Siebenmorgen, R. (2022). Structural formation and functionality of the SpoIIE protein in Clostridium difficile. Biological Sciences Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/biscuht/47