Date of Graduation
5-2025
Document Type
Thesis
Degree Name
Bachelor of Science in Biomedical Engineering
Degree Level
Undergraduate
Department
Biomedical Engineering
Advisor/Mentor
Jensen, Morten
Abstract
Stroke is a prevalent and deadly disorder that causes significant human and economic loss each year. Treatment of stroke is largely done through two routes: intravenous thrombolytic therapy and mechanical thrombectomy. This paper considered a design for a device that combines these two approaches. The device aims to use localized delivery of a thrombolytic agent to a clot site to treat stroke clots. An iterative approach to design was taken to continue to refine device designs generated by previous work. Components, including a balloon for localization, a semi-porous membrane for drug dispersion, and combinations were tested in scaled-up form. Generalizations of the device to allow for other applications of localized intra-arterial drug delivery were also considered.
Keywords
Stroke; Localized, Arterial; Chemotherapy; Drug Delivery; Thrombolytic
Citation
Green, M. P. (2025). Localized Intraarterial Drug Delivery Device. Biomedical Engineering Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/bmeguht/158
