Date of Graduation
12-2019
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Kinesiology (PhD)
Degree Level
Graduate
Department
Health, Human Performance and Recreation
Advisor/Mentor
Michelle Gray
Committee Member
Ro Di Brezzo
Second Committee Member
Nicholas Greene
Third Committee Member
Jamie Baum
Fourth Committee Member
Wen-Juo Lo
Keywords
aging, appendicular skeletal muscle mass, blood biomarkers, IGF-1, myostatin, sarcopenia
Abstract
The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) wherein blood biomarkers (serum myostatin and IGF-1) were examined relative to age and appendicular skeletal muscle mass (ASM). Linear multiple regression analysis was used to identify the model of best-fit to describe the relationship between the primary outcome variable (ASM) and the set of biomarkers (myostatin, IGF-1). RESULTS: The results of the regression model indicated 78% of the variance in ASM to be accounted for when utilizing the four-predictor regression model, considering age, sex, serum myostatin and IGF-1. Neither biomarker significantly contributed to the model and only accounted for
Citation
Binns, A. (2019). Serum Myostatin and IGF-1 as Biomarkers of Sarcopenia: A Proof-of-Concept Design. Graduate Theses and Dissertations Retrieved from https://scholarworks.uark.edu/etd/3523
Included in
Biomechanics Commons, Gerontology Commons, Other Kinesiology Commons, Psychology of Movement Commons