Date of Graduation
12-2019
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Kinesiology (PhD)
Degree Level
Graduate
Department
Health, Human Performance and Recreation
Advisor
Michelle Gray
Committee Member
Ro Di Brezzo
Second Committee Member
Nicholas Greene
Third Committee Member
Jamie Baum
Fourth Committee Member
Wen-Juo Lo
Keywords
aging, appendicular skeletal muscle mass, blood biomarkers, IGF-1, myostatin, sarcopenia
Abstract
The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) wherein blood biomarkers (serum myostatin and IGF-1) were examined relative to age and appendicular skeletal muscle mass (ASM). Linear multiple regression analysis was used to identify the model of best-fit to describe the relationship between the primary outcome variable (ASM) and the set of biomarkers (myostatin, IGF-1). RESULTS: The results of the regression model indicated 78% of the variance in ASM to be accounted for when utilizing the four-predictor regression model, considering age, sex, serum myostatin and IGF-1. Neither biomarker significantly contributed to the model and only accounted for
Citation
Binns, A. (2019). Serum Myostatin and IGF-1 as Biomarkers of Sarcopenia: A Proof-of-Concept Design. Theses and Dissertations Retrieved from https://scholarworks.uark.edu/etd/3523
Included in
Biomechanics Commons, Gerontology Commons, Other Kinesiology Commons, Psychology of Movement Commons