Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging

Authors

Ronald G. Jones III, University of Arkansas, FayettevilleFollow
Ferdinand von Walden, Karolinska InstitutetFollow
Kevin A. Murach, University of Arkansas, FayettevilleFollow

Document Type

Article

Publication Date

4-2024

Keywords

Yamanaka factors; hypertrophy; Geroscience; DNA methylation; biological age

Abstract

Of the “Yamanaka factors” Oct3/4, Sox2, Klf4, and c-Myc (OSKM), the transcription factor c-Myc (Myc) is the most responsive to exercise in skeletal muscle and is enriched within the muscle fiber. We hypothesize that the pulsatile induction of MYC protein after bouts of exercise can serve to epigenetically reprogram skeletal muscle toward a more resilient and functional state.

Citation

Jones, R. G., von Walden, F., & Murach, K. A. (2024). Exercise-Induced MYC as an Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging. Exercise and Sport Sciences Reviews, 52 (2), 63-67. https://doi.org/10.1249/JES.0000000000000333

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