Document Type
Patent
Publication Date
6-23-2015
Abstract
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Department
Chemistry & Biochemistry
Patent Number
US9062300
Application Number
US20130337017 A1
Application Published
12-19-2013
Application Filed
5-20-2013
Assignee
National University Corporation Kagawa University (Kagawa, JP); Ochsner Clinic Foundation (New Orleans, LA); Board of Trustees of the University of Arkansas (Little Rock, AR)
Citation
Gensure, R. C., Sakon, J., Matsushita, O., & Ponnapakkam, T. (2015). Fusion Proteins of Collagen-Binding Domain and Parathyroid Hormone. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/1
Comments
Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR