Document Type

Patent

Publication Date

1-31-2017

Abstract

Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1 and variations thereof. The peptides may contain L or D amino acids and may be circularized, dimerized or otherwise modified to make the compositions resistant to proteolysis. The compositions may be used to inhibit microbial growth and in particular fungal growth.

Department

Chemistry and Biochemistry; Biological Sciences

Patent Number

US9556226

Application Number

US 20160039873 A1

Application Published

2-11-2016

Application Filed

3-14-2014

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with United States government support awarded by the National Institutes of Health grant numbers 1P30RR031154 and P30 GM 103450. The United States may have certain rights in this invention.

Thallapuranam Krishnaswamy Suresh Kumar, Deparment of Chemistry and Biochemistry

David S. McNabb, Deparment of Biological Sciences

Yazan Hussien Akkam, Cell and Molecular Biology Program

Duy Tu Nguyen, Cell and Molecular Biology Program

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