Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Chemistry and Biochemistry
US 20190135890 A1
Board of Trustees of the University of Arkansas (Fayetteville, AR); Ochsner Clinic Foundation (New Orleans, LA); National University Corporation Kagawa university (Kagawa, JP)
Gensure, Robert C.; Sakon, Joshua; Matsushita, Osamu; and Ponnapakkam, Tulasi, "Fusion proteins of collagen-binding domain and parathyroid hormone" (2019). Patents Granted. 360.