Delivery of therapeutic agents by a collagen binding protein

Inventors

Tulasi Ponnapakkam
Sagaya Theresa Leena Philominathan
Joshua Sakon, University of Arkansas, Fayetteville
Ranjitha Katikaneni
Takaki Koide
Osamu Matsushita
Robert C. Gensure

Document Type

Patent

Publication Date

2-26-2019

Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Department

Chemistry & Biochemistry

Patent Number

US10213488

Application Number

US 20170106093 A1

Application Published

4-20-2017

Application Filed

12-21-2016

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR); Kitasato Institute (Tokyo, JP); Montefiore Medical Center (New York, NY)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Citation

Ponnapakkam, T., Philominathan, S. T., Sakon, J., Katikaneni, R., Koide, T., Matsushita, O., & Gensure, R. C. (2019). Delivery of therapeutic agents by a collagen binding protein. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/370