Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
US 20200297832 A1
Board of Trustees of the University of Arkansas (Little Rock, AR); Texas A&M University System (College Station, TX)
Bielke, L. R., Layton, S., Hargis, B., Pumford, N. R., Faulkner, O. B., Berghman, L., & Abi-Ghanem, D. (2021). Compositions and methods of enhancing immune responses to enteric pathogens. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/414