Document Type
Article
Publication Date
12-2024
Keywords
inflammatory response; lipopolysaccharide; peptidoglycan; chicken; leukocyte; lymphocytes; cytokines; innate immunity; microbe associated molecular patterns
Abstract
The innate immune system plays an important role in the early defense against pathogens. To better understand the chicken’s innate inflammatory responses, we concurrently examined the cellular responses at the injection site and in the blood following intradermal (i.d.) injections of lipopolysaccharide (LPS) or peptidoglycan (PGN) into the pulp of growing feathers (GFs). Both LPS from Gram-negative bacteria and PGN from Gram-positive bacteria are potent stimulators of innate inflammatory responses. The time-course study conducted revealed similarly elevated levels of heterophils and macrophages in injected GF-pulps during the first 24 h for both LPS and PGN. However, PGN also stimulated rapid infiltration of lymphocytes, with high levels sustained for 7 days post-injection. The i.d. injection of LPS also affected leukocyte profiles in the blood, whereas PGN did not. Overall, the temporal, qualitative, and quantitative differences in the inflammatory responses to LPS and PGN suggest different innate immune response mechanisms in the defense against infection with Gram-negative and Gram-positive bacteria in chickens.
Citation
Byrne, K. A., & Erf, G. F. (2024). The Bacterial Cell Wall Components Lipopolysaccharide and Peptidoglycan Initiate Divergent Local Tissue and Systemic Inflammatory Response Profiles in the Chicken Model. Animals, 14 (24), 3661. https://doi.org/10.3390/ani14243661
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Included in
Agriculture Commons, Dairy Science Commons, Veterinary Medicine Commons, Zoology Commons
