Document Type
Article
Publication Date
12-2024
Keywords
acetogenins; antibacterial activity; nanosuspensions; poultry sector
Abstract
This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-β-cyclodextrin (βCD) named NSps-βCDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-βCDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-βCDSL-ACGs presented nanometric size (207–239 nm), acceptable polydispersity index (PDI) values (0.13–0.17) and a high Z potential value (−47.17–50.36 mV), demonstrating high stability. The presence of ACGs in NSps-βCDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical shape and exhibited high inhibition potential against Salmonella Enteritidis (88.18%), Streptococcus gallolyticus (88.01%), Salmonella Typhimurium (86.28%) and Salmonella Infantis (77.02%) strains up to 48 h, and a reduction of up to 3 log CFU/mL was achieved for S. Typhimurium. Therefore, NSps-βCDSL-ACGs is an attractive option for implementing ACGs administration in the poultry sector to reduce the use of antibiotics and minimize bacterial resistance.
Citation
Lopez-Romero, B. A., Aguilar-Hernandez, G., Hargis, B. M., Garcia-Magana, M. d., Lopez-Garcia, U. M., Ortiz-Basurto, R. I., Zamudio-Ojeda, A., Latorre, J. D., & Montalvo-Gonzalez, E. (2024). Characterization of an Acetogenin-Carrying Nanosuspension and Its Effect on Bacteria of Interest in the Poultry Industry. Microorganisms, 13 (1), 18. https://doi.org/10.3390/ microorganisms13010018
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
