Pure and Commercial samples of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5- T) were tested on Swiss-Webster mice for: (1) interruption of the estrus cycle and (2) teratogenic effects. The estrus cycle of mice administered Commercial 2,4,5-T was interrupted in 42.9% of the animals and in 12.5% of the animals given Pure 2,4,5-T. No fetal abnormalities were found in pregnant animals treated with Commercial or Pure 2,4,5-T. Fetal resorptions were found in both treatment groups. Treatment with Pure 2,4,5-T produced a significant decrease in viable fetal weight and increased fetal deaths.
Greer, Gerald S.
"Effects of 2, 4, 5-Trichlorophenoxyacetic Acid on Swiss-Webster Mice,"
Journal of the Arkansas Academy of Science: Vol. 31
, Article 15.
Available at: http://scholarworks.uark.edu/jaas/vol31/iss1/15