Miniaturized multielectrode arrays are MEMS devices that have found use as neural prosthetics (Neuro-MEMS). As implants, they can interface with neurons as sensors or actuators and help compensate for loss of sensory input, motor control, or cognitive functions. The microelectrodes studied here were developed in-house. They have a vertically aligned gold nanowire array and are mounted on a sturdy titanium needle with a fine gauge. Hence, the bill of materials and design characteristics encourage their use as a neural probe. For this study, a probe was tested in vivo for signal acquisition in the hippocampus of a Rattus Norvegicus (Sprague Dawley Rat). Using an Institutional Animal Care and Use Committee (IACUC) approved protocol, the neural probe was deployed in the CA1 region of the hippocampus of a sedated rat. The signal was obtained as voltage against time and was filtered for isolated spikes of neural activity, which were sorted in the form of a Spike Train-Raster Plot. The qualitative evaluation of data obtained through the newly developed neural probe was used as groundwork to decide on future research and discuss possible clinical impacts.
Kegley, L. (2010). In-Vivo Testing of Vertically Aligned Nanowire Implantable Titanium Electrodes in the Rattus Norvegicus Hippocampus. Inquiry: The University of Arkansas Undergraduate Research Journal, 11(1). Retrieved from https://scholarworks.uark.edu/inquiry/vol11/iss1/12