The objective of most taste research involving choice is to eliminate from the experiment all cues to the animal except those that are strictly gustatory. Among those potentially confounding cues, one of the most obvious is olfaction, although it often remains uncontrolled in taste experiments. The present report clearly demonstrates the role played by olfaction in a discrimination experiment with C57B1/6 and CFW mice as regards their response to phenylthiocarbamide (PTC) when paired with water. The results have implications for conclusions drawn by other investigators who have attributed differences in PTC sensitivity in mice to taste alone.

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