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Abstract

In vivo 31P NMR studies recently have shown that cocaine causes an imbalance of the free magnesium in the brain which results in pH lowering, ischemia, and even death. This direct interaction with the free Mg+2 inthe brain also affects the Ca+2 balance which controls arterial and vascular contraction. This research has addressed the mechanism of the cocaine interaction withmagnesium adenosine 5-triphosphate (ATP) using 31P, 13C, and 1H NMR using a Bruker 200 MHz nuclear magnetic resonance (NMR) system. Data are presented and discussed which shows that cocaine and ATP form a complex species which directly affects the NMR spectra.

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