Association of Single Nucleotide Polymorphisms in Bovine Heat Shock Protein 70, Cytochrome P450, Lactate Dehydrogenase, Interleukin 8 Receptor, and Melatonin Receptor 1A with Hoof and Udder Traits in Beef Cows
Date of Graduation
Bachelor of Science in Agricultural, Food and Life Sciences
Committee Member/Second Reader
Hoof and udder conformation are important to the longevity and productivity of beef cattle. Selection for hoof and udder quality reduces the incidence of lameness and udder disease to improve animal welfare. Genetic selection is an effective means of improving traits such as these, especially through the use of single nucleotide polymorphism (SNP) genotyping to identify indicator traits. This study used genotype data and hoof and udder scores from previous research to determine if there is significant effect between polymorphisms of heat shock protein 70 (Hsp70), cytochrome P450 (CYP450), interleukin-8 receptor (IL8), lactate dehydrogenase (LDH), and melatonin receptor 1A (MTNR1A), and hoof and udder traits in (n=76) beef cows. The SNP site A1125C of Hsp70 affected hoof angle (P<0.0006) and claw set (P=0.0007). The SNP C994G of Cytochrome P450 affected hoof angle (P<0.0024), and claw set (P=0.0054). The SNP C541A of LDH affected teat size (P<0.0001), and the SNP G777C of IL8 receptor affected udder suspension (P=0.0355). The MTNR1A receptor had two polymorphisms G497A, which affected teat size (P=0.032) and hoof angle (P<0.01), and A455G, which affected udder suspension (P=0.0004) and teat size (P=0.02). These results suggest that Hsp70, CYP450, IL8 receptor, LDH, and MTNR1A genes could be markers for selection of hoof and udder traits in cattle.
hoof traits, udder traits, polymorphisms, beef genetics
Warren, M. (2020). Association of Single Nucleotide Polymorphisms in Bovine Heat Shock Protein 70, Cytochrome P450, Lactate Dehydrogenase, Interleukin 8 Receptor, and Melatonin Receptor 1A with Hoof and Udder Traits in Beef Cows. Animal Science Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/anscuht/38
Available for download on Saturday, May 08, 2021