Keywords
cGAS-STING signalling, cancer, immune system, molecular biology, cancer immunotherapy
Abstract
Cancer cells have unstable chromosomes and damaged DNA, which can activate the cellular alarm system cGAS-STING. This mechanism detects DNA in the incorrect location (the cytosol) and produces type I interferons, which can recruit immune cells to combat cancer. However, certain tumours can bypass or use this mechanism for their own benefit. This short article examines how cGAS-STING influences the different cells of the tumour microenvironment (TME), and how it can have both anti-tumour and pro-tumour effects. It also demonstrates how additional STING signals can cause inflammation and contribute to cancer growth. To employ cGAS-STING against cancer, it is critical to understand its complexities in various cell environments.
Recommended Citation
Datta, N. (2024). Deciphering the Double-Edged Action of STING pathway in Cancer. Inquiry: The University of Arkansas Undergraduate Research Journal, 23(1). Retrieved from https://scholarworks.uark.edu/inquiry/vol23/iss1/7
