Method of producing active immunity with vaccine conjugate

John A. Thoma, University of Arkansas, Fayetteville
Eid E. Haddad
Craig E. Whitfill
Alan P. Avakian

John A. Thoma, Department of Chemistry and Biochemistry


Describes a method of producing active immunity against a bacterial or protozoal disease in a subject. It comprises administering to the subject a vaccine conjugate comprising a live bacterial or protozoa and a neutralizing factor bound to the live bacterial or protozoa. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live bacterial or protozoa is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live bacteria or protozoa.