Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
Animal Science; Food Science; Poultry Science
US 20150216954 A1
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (Little Rock, AR), TEXAS A&M UNIVERSITY SYSTEM (College Station, TX)
Bottje, Walter G.; Hargis, Billy M.; Berghman, Luc; Kwon, Young M.; Cole, Kimberly; Cox, Mandy; Layton, Sherryll; El-Ashram, Saeed; Barta, John; and Tellez, Guillermo L., "Compositions and methods of enhancing immune responses to Eimeria" (2018). Patents Granted. 347.