Provided herein are peptoids capable of inhibiting or reversing amyloid .beta. (A.beta.) fibril or plaque production. The peptoids form a helical structure with three monomers per helical turn and have at least four monomers with a side-chain having an arylalkyl or aryl group. The peptoid may be achiral. Also provided are methods of using the peptoids to inhibit or reverse aggregation of A.beta. and methods of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD.
US 20160376311 A1
Board of Trustees of the University of Arkansas (Little Rock, AR); University of South Carolina (Columbia, SC)
Servoss, S., Moss, M., & Turner, J. P. (2019). Peptoids and methods for treating Alzheimer's disease. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/352
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with United States government support under grant numbers 1P30RR031154-02 and 8P30GM103450-03 from the National Institutes of Health and the National Center for Research Resources, respectively. The United States government has certain rights in this invention.
Shannon Servoss, Department of Chemical Engineering, University of Arkansas, Fayetteville, AR