Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
US 20160038581 A1
Board of Trustees of the University of Arkansas (Fayetteville, AR); The Texas A&M University System (College Station, TX)
Bielke, Lisa R.; Layton, Sherryll; Hargis, Billy M.; Pumford, Neil R.; Faulkner, Olivia B.; Berghman, Luc; and Abi-Ghanem, Daad, "Compositions and methods of enhancing immune responses to enteric pathogens" (2019). Patents Granted. 358.