Document Type

Patent

Publication Date

12-31-2019

Abstract

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

Department

Chemistry and Biochemistry

Patent Number

US10519213

Application Number

US 20190338010 A1

Application Published

11-7-2019

Application Filed

7-22-2019

Assignee

Board of Trustees of The University of Arkansas (Little Rock, AR) (Little Rock, AR); Ochsner Clinic Foundation (New Orleans, La); National University Corporation Kagawa University (Kagawa, Jp)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Share

COinS