Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
Chemistry and Biochemistry
US 20190338010 A1
Board of Trustees of The University of Arkansas (Little Rock, AR) (Little Rock, AR); Ochsner Clinic Foundation (New Orleans, La); National University Corporation Kagawa University (Kagawa, Jp)
Gensure, R. C., Sakon, J., Matsushita, O., & Ponnapakkam, T. (2019). Fusion proteins of collagen-binding domain and parathyroid hormone. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/377