Document Type
Patent
Publication Date
5-28-2013
Abstract
Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.
Department
Chemistry & Biochemistry
Patent Number
US8450366
Application Number
US20100331370
Application Published
12-30-2010
Application Filed
6-30-2010
Assignee
Board of Trustees of the University of Arkansas (Little Rock, AR)
Citation
McIntosh, M. C. (2013). Isobenzofuran analogs of sclerophytin A. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/38
COinS
Comments
STATEMENT OF GOVERNMENT SUPPORT The present invention has been supported in part by NIH Grants CA75577, RR15569, CA125602 and CA109821. The Government has certain rights in the invention.
Matthias C. McIntosh, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR