Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.
Chemistry & Biochemistry
Board of Trustees of the University of Arkansas (Little Rock, AR)
McIntosh, M. C. (2013). Isobenzofuran analogs of sclerophytin A. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/38
STATEMENT OF GOVERNMENT SUPPORT The present invention has been supported in part by NIH Grants CA75577, RR15569, CA125602 and CA109821. The Government has certain rights in the invention.
Matthias C. McIntosh, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR