Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC 50's as low as 1 micro M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one of the following structural formulas, where R is hydrogen or a substituted or unsubstituted lower alkyl group and Ar is a substituted or unsubstituted aryl group.
Chemistry & Biochemistry
Board of Trustees of the University of Arkansas (Little Rock, AR)
McIntosh, M. C. (2013). Isobenzofuran analogs of sclerophytin A. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/38