Analysis of phase II metabolites of methamphetamine by solid-phase extraction and liquid chromatography with tandem mass spectrometric detection
Date of Graduation
Bachelor of Science in Biological Engineering
Biological and Agricultural Engineering
Methamphetamine (METH) abuse is one of the most serious health problems in the United States and Europe due to its addictive properties and potential neurotoxic effects [1, 2, 3]. METH abuse appears to have stabilized or decreased slightly in the general populations, however abuse in certain populations is increasing [4, 5]. Treatments for drug abuse are often tested in animal behavioral pharmacology models. One of the first in vivo tests conducted in animals is to follow the concentration of the drug and its metabolites as a function of time. In this way, one can determine how long a potential medication must be active and one can decide if specific tissues are potentially better targets for medication.
methamphetamine, spectrometer, drug abuse
Carbary, J., & Hendrickson, H. P. (2009). Analysis of phase II metabolites of methamphetamine by solid-phase extraction and liquid chromatography with tandem mass spectrometric detection. Biological and Agricultural Engineering Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/baeguht/33