Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis
Alkynes, [3+2] annulation, Cyclopropylanilines, Diynes, Enynes, Intermolecular annulation, Photocatalysis, Visible light
One‐step syntheses of carbocycles substituted with amines from simple starting materials remain rare. We recently developed an intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enables this one‐step synthesis. Herein, we report our findings for a full‐scale study of the annulation. Significant expansion of the substrate scope for both cyclopropylanilines and alkynes has been achieved. A range of structurally diverse carbocycles substituted with amines is prepared.
Nguyen, T. H., Morris, S. A., & Nan, Z. (2014). Intermolecular [3+2] Annulation of cyclopropylanilines with alkynes, enynes, and diynes via visible light photocatalysis. Advanced Synthesis & Catalysis, 356(13), 2831-2837. doi:10.1002/adsc.201400742