Intermolecular [3+2] Annulation of Cyclopropylanilines with Alkynes, Enynes, and Diynes via Visible Light Photocatalysis

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Article - Abstract Only

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Alkynes, [3+2] annulation, Cyclopropylanilines, Diynes, Enynes, Intermolecular annulation, Photocatalysis, Visible light


One‐step syntheses of carbocycles substituted with amines from simple starting materials remain rare. We recently developed an intermolecular [3+2] annulation of cyclopropylanilines with alkenes and alkynes that enables this one‐step synthesis. Herein, we report our findings for a full‐scale study of the annulation. Significant expansion of the substrate scope for both cyclopropylanilines and alkynes has been achieved. A range of structurally diverse carbocycles substituted with amines is prepared.


Principal Investigator: Nan Zheng

Acknowledgements: This publication was supported by the University of Arkansas, Arkansas Bioscience Institute, National Institute of General Medical Sciences of the National Institutes of Health (NIH) (Grant Number P30 GM103450), NSF Career Award under Award Number CHE‐1255539.

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