Title

Glycoside Hydrolysis with Sugar-Templated Microgel Catalysts

Document Type

Article

Publication Date

2012

Keywords

binuclear copper complex, carbohydrate, catalysis, hydrolysis, microgel

Abstract

Water-soluble, carbohydrate-templated microgels are explored as catalysts for the hydrolysis of glycosidic bonds. The reaction is more than 2 orders of magnitude accelerated for templated macromolecular catalysts over low-molecular-weight complexes. The structure of the carbohydrate used as template during material preparation directs the catalytic performance of the catalysts to differentiate epimeric substrates.

Comments

A CAREER award from the National Science Foundation (CHE-0746635) to S.S. is gratefully acknowledged; the authors are indebted to Mike Miller for TEM imaging experiments.

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