Discrimination of chiral copper(II) complexes upon binding of galactonoamidine ligands
Document Type
Article
Publication Date
2016
Keywords
N-p-methylbenzyl-D-galactonoamidine, spectroscopic titration, isothermal titration calorimetry, circular dichroism spectroscopy, potent inhibitors, glycosidases
Abstract
The coordination between N-p-methylbenzyl-D-galactonoamidine, a putative transition state analogue of the hydrolyis of glycosidic bonds, and symmetric and chiral binuclear copper(II) complexes was characterized by spectroscopic titration, isothermal titration calorimetry, circular dichroism spectroscopy, and DFT calculations to elucidate the binding sites in the carbohydrate upon coordination to selected metal complexes. For the formation of metal complex-glyconoamidine assemblies, contributions of the amidine site and of the hydroxyl group at C-2 in the glycon of the amidine are noted. The chiral complexes S- and R-Cu2bpdbo are discriminated by a third binding site in the carbohydrate that leads to higher stability of complexes derived from S-Cu2bpdbo (4–5 kcal mol−1) compared to those formed from R-Cu2bpdbo.
Citation
Striegler, S., & Pickens, J. (2016). Discrimination of chiral copper(II) complexes upon binding of galactonoamidine ligands. Dalton Transactions (38) https://doi.org/10.1039/C6DT02153K
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Comments
Support of this research to S.S. by the National Science Foundation (CHE-1305543), the Arkansas Biosciences Institute, access to PQSmol.