Title

Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow

Document Type

Article

Publication Date

2016

Keywords

Photocatalysis, Continuous flow, N-cyclobutylaniline, [4+2], Annulation, Visible light

Abstract

Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.

Comments

Principal Investigator: Nan Zheng

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