Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow
Photocatalysis, Continuous flow, N-cyclobutylaniline, [4+2], Annulation, Visible light
Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.
Wang, J., Nguyen, T.H. & Zheng, N. Sci. China Chem. (2016) 59: 180. https://doi.org/10.1007/s11426-015-5547-y