Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow

Authors

Jiang Wang, University of Arkansas, FayettevilleFollow
Theresa H. Nguyen, University of Arkansas, FayettevilleFollow
Nan Zheng, University of Arkansas, FayettevilleFollow

Document Type

Article - Abstract Only

Publication Date

2016

Keywords

Photocatalysis, Continuous flow, N-cyclobutylaniline, [4+2], Annulation, Visible light

Abstract

Continuous flow has recently emerged as a powerful enabling technology that greatly improves many reactions’ efficiency. Here, we apply the technology to intermolecular [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes by photoredox catalysis. An across-the-board improvement in the annulation’s efficiency is noticed. Moreover, a gram-scale annulation is successfully demonstrated in continuous flow using a much lower catalyst loading.

Comments

Principal Investigator: Nan Zheng

Citation

Wang, J., Nguyen, T. H., & Zheng, N. (2016). Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow. Science China Chemistry, 59, 180-183. https://doi.org/10.1007/s11426-015-5547-y