Date of Graduation


Document Type


Degree Name

Master of Science in Kinesiology (MS)

Degree Level



Health, Human Performance and Recreation


Stavros Kavouras

Committee Member

Matthew Ganio

Second Committee Member

Tyrone Washington


Cellular Dehydration, Glucose Regulation, Vasopressin


A chronically elevated vasopressin level has been associated with an impaired glucose regulation system in humans. A recent study in patients with diabetes suggested that low water intake is associated with impaired glucose regulation. The aim of this study was to examine the effect of hypertonic saline infusion on glucose regulation in healthy females. Thirty healthy, non-diabetic females performed a 2-h infusion followed by a 4-h oral glucose tolerance test (OGTT). Every subject participated in two trials separated by one month, in a counterbalanced order. Two trials were identical in the procedure, differing in the concentration of saline infusion, with one trial being 3% NaCl (HYPER), another being 0.9% NaCl (ISO). The HYPER trial led to an increase in plasma osmolality (time point 0 min, 305±0.91 vs. 287±0.61 mmol/kg, P