Date of Graduation
8-2012
Document Type
Dissertation
Degree Name
Doctor of Philosophy in Chemistry (PhD)
Degree Level
Graduate
Department
Chemistry & Biochemistry
Advisor/Mentor
Matthias C. McIntosh
Committee Member
Robert Gawley
Second Committee Member
Neil Allison
Third Committee Member
Wesley Stites
Keywords
Pure sciences, Antascomicin B., Asymmetric transfer hydrogenation, Organic, Total synthesis
Abstract
The following dissertation describes synthetic efforts toward the synthesis of the C21-C34 fragment of antascomicin B. Our initial enzymatic approach is detailed as well as an asymmetric transfer hydrogenation (ATH) strategy that will be used in the eventual total synthesis of the molecule. Several investigations into anomalies observed during (ATH) reactions are also discussed.
Citation
Clay, D. R. (2012). Studies Toward the Total Synthesis of Antascomicin B. Graduate Theses and Dissertations Retrieved from https://scholarworks.uark.edu/etd/550