Date of Graduation


Document Type

UAF Access Only - Thesis

Degree Level



Health, Human Performance and Recreation


Gray, Michelle

Committee Member/Reader

Sullivan, Amanda


Cognitive impairment effects a large population. To slow the rate of cognitive decline, physical activity is a beneficial tool used for women. A supplement called inositol-stabilized arginine silicate (Nitrosigine® or ASI) has been shown to increase cognitive flexibly and athletic performance by escalating nitric oxide production. Therefore, the proposed research is to evaluate the effects of Nitrosigine® in females with different activity levels on various cognitive tasks. Fifteen young females ages 18-25 completed a randomized, double blind, study consuming Nitrosigine® (1.5 g Nitrosigine® + 12 g detrose) and placebo (12 g dextrose). The participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Visual Paired Comparison (VPC Neurotrack Technologies, Inc.) before consuming the supplement and then completed the same battery of test 60 minutes post-supplementation. A 3 (physical activity) x 2 (supplement) repeated measure ANOVA demonstrated that Nitrosigine® did significantly improve immediate memory scores when comparing the supplement to placebo group (p < 0.05). There was a trend for an improvement in total index and total percentile scores between supplement and placebo group (p < 0.1). However, there was no significant difference between physical activity groups and supplement (p > 0.05). More research needs to be done on Nitrosigine® to determine if activity level in women effects cognitive performance.


cognitive impairment, Nitrosigine, cognitive function, physical activity, memory