Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
Chemistry & Biochemistry
US 20150038423 A1
Kitasato Institute (Tokyo, JP); Montefiore Medical Center (New York, NY); Board of Trustees of the University of Arkansas (Little Rock, AR)
Ponnapakkam, T., Philominathan, S. T., Sakon, J., Katikaneni, R., Koide, T., Matsushita, O., & Gensure, R. C. (2016). Delivery of therapeutic agents by a collagen binding protein. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/335
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with United States government support awarded by the National Institutes of Health grant number NCRR COBRE 8P30GM103450 and INBRE GM103429. The United States may have certain rights in this invention.
Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR