Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
US 20150190500 A1
Board of Trustees of the University of Arkansas (Little Rock, AR)
Berghman, Luc; Bottje, Walter G.; Hargis, Billy M.; and Layton, Sherryll, "Vaccine vectors and methods of enhancing immune responses" (2018). Patents Granted. 339.